Updated June 2026 · Your Australian guide to choosing the best PDRN serum.
Short answer: the best PDRN serum isn't the one with the highest number on the box. PDRN (polydeoxyribonucleotide, derived from salmon DNA) works best in a well-formulated topical at a sensible concentration, paired with delivery ingredients like exosomes. Below we compare five salmon DNA skincare ranges available in Australia: Vitaran, Curenex, Medicube, Dr. Drawing and Rejuran, so you can choose with confidence.
If you're a skincare lover who's seen the "pink" PDRN buzz everywhere, this guide breaks down what actually matters in a PDRN serum so you're not swayed by marketing alone.
Is more PDRN always better? The truth about concentration
You might assume "the more PDRN, the better," but formulation science suggests otherwise. Very high concentrations are not automatically more effective for a topical product, and a balanced formula often performs better day to day.
- A sensible range works well: many topical PDRN serums are formulated in the 2,000-5,000 ppm range.
- Formula beats a big number: supporting actives and a good delivery system matter as much as the headline ppm.
- Delivery counts: ranges like Vitaran pair PDRN with exosomes and NMN. Think of exosomes as tiny carriers that help other ingredients absorb into the skin.
- Know your source: "plant" or "vegan PDRN" is not the same molecule as marine (salmon-derived) PDRN, and is less well studied.
- PDRN isn't new: it has been used in Korean skincare for over a decade. It's simply newer to the Australian skincare market.
Meet the salmon DNA skincare ranges
Vitaran Skin Healing Series
- PDRN: 5,000 ppm, paired with a layered actives-delivery formula.
- Key actives: 5% exosomes, NMN (a precursor to NAD+), Centella, Adenosine, Niacinamide, Azulene.
- Technology: capsule technology helps keep actives stable until application. The capsules burst as you massage the product in.
- Best for: a multi-step routine focused on the appearance of hydration, even tone and barrier comfort.
- Shop the Vitaran range →
Curenex Clinical PDRN Range
Newly available in Australia and, like Vitaran, focused on high-purity salmon DNA skincare designed to pair beautifully with at-home microneedling. The formulas suit targeted use, deep cosmetic hydration and post-treatment comfort. If you already microneedle at home, Curenex is a strong companion range, and the daily skincare plus the Snow Peel (a gentle spicule-based home exfoliating treatment) are lovely additions. Browse the Curenex range here.
Medicube PDRN Pink Peptide Serum
- PDRN: stated 10,000 ppm (plant-derived PDRN).
- Key actives: salmon collagen, peptides, Q10, niacinamide, turmeric, hyaluronic acid.
- Texture: lightweight, non-sticky.
- Best for: simple daily routines.
Dr. Drawing Salmon DNA Series
- PDRN: not disclosed by the manufacturer.
- Key actives: hyaluronic acid, niacinamide, collagen, adenosine, Centella Asiatica, EGF complex.
- Format: ampoules suited to microneedling routines.
- Best for: post-routine comfort.
Rejuran Skincare Range
- PDRN/PN: varies by product (Turnover Ampoule ~0.5% c-PDRN / 5,000 ppm).
- Key actives: salmon DNA (PN/PDRN), hyaluronic acid, botanicals.
- Format: serums, essences and ampoules.
- Best for: cosmetic hydration and a refreshed look.
Salmon DNA skincare comparison
| Brand | PDRN / PN | Standout actives | Best for | Use |
|---|---|---|---|---|
| Medicube | 10,000 ppm plant PDRN | Peptides, collagen, Q10 | Simple daily use | Home |
| Dr. Drawing | Not disclosed | Hyaluronic acid, EGF | Post-routine comfort | Clinic & home |
| Vitaran | 5,000 ppm + 5% exosomes | Exosomes, NMN, capsule tech, HA | Multi-step routine, hydration & tone | Clinic & home |
| Rejuran Turnover | 5,000 ppm | Hyaluronic acid | Cosmetic hydration | Home & clinic |
| Curenex | 5,000 ppm (varies) | High-purity salmon DNA, HA, peptides | Microneedling companion, hydration | Clinic & home |
Our pick for a topical salmon DNA routine: Vitaran
For an everyday, multi-step PDRN routine, the Vitaran Skin Healing Series is our standout. It pairs 5,000 ppm PDRN with exosomes, azulene, niacinamide and NMN, so you're supporting the look of your skin from several angles rather than relying on one big number.
The Vitaran three-step routine
Step 1: Dual Serum: 5,000 ppm PDRN + 5% cica exosomes, with Centella, Adenosine and Niacinamide for daily radiance and a smoother-looking finish.
Step 2: Azulene Serum: a soothing, comforting layer with guaiazulene and niacinamide, a nice choice for sensitive-feeling or post-routine skin.
Step 3: Capsule Cream: NMN plus capsule-fresh actives and 24-hour hydration to finish.
Get the complete Vitaran 3-step bundle →
Where Vitaran is made
Vitaran is manufactured by BR Pharm in South Korea, who specialise in PDRN raw material and produce several established cosmetic brands. Vitaran sold at Salmon DNA Australia is purchased directly from the manufacturer, stocked in Brisbane and shipped Australia-wide via Australia Post.
How much does a PDRN serum cost in Australia?
PDRN serum prices in Australia vary with concentration, format and brand, but most topical salmon DNA serums sit somewhere between roughly $40 and $150. Single serums tend to be at the lower end, while multi-step sets and capsule-technology ranges like Vitaran sit higher because you're buying a full routine rather than one bottle. Buying from an Australian stockist (rather than grey-importing) means local AUD pricing, faster shipping and genuine product. You can compare current pricing across the PDRN serum collection.
How to use a PDRN serum
A PDRN serum slots easily into a normal routine. On clean, slightly damp skin, apply the serum before your moisturiser, morning and/or night, then follow with SPF during the day. If you microneedle at home, press a PDRN serum in straight afterwards, when skin is most receptive. PDRN is gentle and fragrance-light, so it layers comfortably under the rest of your routine. For a full schedule, see How often should you use PDRN?
PDRN serum vs Rejuran injections: what's the difference?
This is the question that confuses the most people. "Rejuran" is best known as an injectable polynucleotide treatment given by a trained clinician — it's a therapeutic procedure, not something you do at home. A topical PDRN serum delivers salmon DNA to the surface of the skin as a cosmetic, with no needles and no downtime. They aren't the same thing and aren't directly comparable; a serum is the gentle, at-home way to bring salmon DNA into your routine. For the full breakdown, read What is PDRN? and our Rejuran vs Curenex vs VITARAN comparison.
Where to buy PDRN serum in Australia
You'll find PDRN serums through Korean-skincare retailers and, increasingly, dedicated salmon DNA stores. Buying locally matters: an Australian stockist means genuine product, local support, fast domestic shipping and pricing in AUD. Salmon DNA Australia stocks Vitaran, Curenex, Jeunetique and more, shipped from Brisbane Australia-wide. Start with the PDRN serum collection or explore a salmon DNA bundle.
How to choose your PDRN serum
No matter your age or skin goals, there's a salmon DNA option to suit you. Remember: it's not about the highest PDRN number, it's about the smartest formula and a delivery system that helps the actives absorb. Browse the full PDRN serum collection or explore salmon DNA bundles to start your routine.
Frequently asked questions
What is a PDRN serum?
A PDRN serum is a topical skincare product containing polydeoxyribonucleotide, fragments of DNA most often sourced from salmon. In cosmetics it's used to support the appearance of hydrated, smooth, even-looking skin.
What's the best PDRN serum in Australia?
The "best" depends on your routine. For a multi-step approach with exosomes and NMN, many shoppers choose the Vitaran Skin Healing Series; for a microneedling companion, Curenex is a popular high-purity option.
Is a higher PDRN ppm better?
Not necessarily. A balanced concentration in a well-formulated serum with good supporting actives is generally more useful than chasing the highest number on the label.
Is salmon-derived PDRN the same as plant or vegan PDRN?
No. Marine (salmon-derived) PDRN and plant/vegan alternatives are different and are not directly comparable; salmon-derived PDRN is the more established option in skincare.
How much does a PDRN serum cost in Australia?
Most topical PDRN (salmon DNA) serums in Australia range from around $40 to $150, depending on concentration, format and whether you're buying a single serum or a full multi-step set.
Can I use a PDRN serum every day?
Yes. PDRN is gentle and fragrance-light, so most people use it daily, morning and/or night, on clean skin before moisturiser. Patch test first if your skin is reactive.
PDRN serum vs Rejuran — which is better?
They're different categories. Rejuran is best known as an in-clinic injectable; a PDRN serum is a topical cosmetic you use at home with no downtime. A serum is the gentle, needle-free way to use salmon DNA day to day.
Where can I buy PDRN serum in Australia?
Through Australian Korean-skincare and salmon DNA stockists. Buying locally means genuine product, AUD pricing and fast domestic shipping — Salmon DNA Australia ships Vitaran, Curenex and more from Brisbane.
Disclaimer: These are cosmetic skincare products. Always patch test before use. Not suitable for those with fish allergies. If you have a specific skin condition, consult your healthcare provider.
