PDRN is one of the most talked-about ingredients in Korean skincare right now but between the science-y name and the "salmon DNA" headlines, it's easy to feel lost. This guide breaks it down simply: what PDRN actually is, what it does for skin, what the percentages mean, and how to choose and use a PDRN serum at home in Australia.
What PDRN actually is
PDRN stands for polydeoxyribonucleotide a bit of a mouthful, which is why most people just call it salmon DNA. It's a purified fragment of DNA, most commonly sourced from salmon, prepared specifically for use in skincare.
Why salmon? Salmon DNA is remarkably compatible with human skin, which is why it's become a hero ingredient in K-beauty serums, skin boosters, masks and creams. You may also see it referred to as a "salmon sperm facial" online that's just a nickname; it's salmon DNA, not sperm. (We cleared that one up in our salmon sperm facial explainer.)
What PDRN does for skin
In cosmetic skincare, PDRN is valued for supporting the look of healthier, more refreshed skin. It's most associated with:
- Hydration helping skin look plumper, dewier and more comfortable.
- Firmness and bounce supporting a smoother, more youthful-looking surface.
- Radiance that even, luminous "glass skin" finish K-beauty is known for.
- Soothing the look of stressed skin often why it's reached for after treatments like microneedling.
You'll rarely find PDRN working alone. Good formulations pair it with ingredients like hyaluronic acid, peptides, glutathione, growth factors and exosomes to round out the result.
PDRN vs polynucleotides vs exosomes vs NAD+
These four terms get used interchangeably online, but they're not the same thing. Here's a quick decoder:
| Ingredient | What it is | Best known in skincare for |
|---|---|---|
| PDRN (salmon DNA) | Purified DNA fragments from salmon | Hydration, firmness, glow; soothing the look of skin |
| Polynucleotides (PN) | Longer-chain DNA fragments (a "cousin" of PDRN) | Often positioned for firmness and skin quality |
| Exosomes | Tiny messenger vesicles that help carry actives | A delivery technology — helps ingredients reach deeper layers |
| NAD+ | A coenzyme involved in cellular energy | Increasingly paired with PDRN in advanced boosters |
The short version: PDRN and polynucleotides are closely related forms of salmon DNA; exosomes are a delivery technology often combined with PDRN; and NAD+ is a separate active that's increasingly layered in. Many of the best skin boosters combine several of these. (Browse our exosome skincare range.)
What the PDRN percentage means
You'll see PDRN serums advertised with a percentage 1%, 2%, 3%. The percentage refers to the concentration of PDRN in that topical formulation. A higher percentage means more of the active ingredient per application.
A few honest caveats so you can shop wisely:
- More isn't automatically "better" for everyone. A higher concentration suits people wanting a more intensive topical experience; a lower one can suit gentler routines or the delicate eye area.
- Percentages only compare like with like. A topical serum's percentage isn't directly comparable to an in-clinic injectable, which is a different product delivered a different way (more on that below).
For a high-concentration topical option, our Jeunetique EXOsomes & PDRN 3% offers 3% PDRN among the highest topical salmon DNA concentrations available in Australia combined with exosomes.
Topical vs microneedling vs injectable PDRN
PDRN shows up in three very different formats, and knowing the difference helps you choose:
- Topical PDRN serums, boosters, masks and creams you apply at home. A cosmetic routine; the easiest, lowest-commitment way to use salmon DNA regularly.
- PDRN with at-home microneedling applying a PDRN booster alongside a microneedling routine, which helps the serum reach deeper layers of the skin. Still a cosmetic, at-home approach.
- In-clinic injectable PDRN treatments such as Rejuran, where PDRN is delivered by injection by a trained professional. This is a medical/clinical procedure, not a cosmetic product, and it's a different category to the topical skincare we stock. It isn't something you do at home, and a topical serum isn't a substitute for it they're different approaches for different needs.
If you're drawn to the ingredient and want to use it consistently without a clinic visit, topical PDRN skincare is where most people begin.
How to choose a PDRN serum
A simple way to narrow it down:
- New to PDRN? Start with a daily salmon DNA serum or skin booster and build from there. (Browse our PDRN serums & skin boosters.)
- Want maximum topical concentration? Look for a higher percentage plus exosomes like our Jeunetique 3%. and Vitaran Skin Healing Series
- Targeting the under-eye area? Choose a gentler, eye-specific option such as Curenex Eye PN.
- Building a full routine? Layer a cleanser, booster/serum, moisturiser and SPF from the same salmon DNA range so everything works together.
Whatever you choose: patch-test first, follow the directions on the packaging, and if you have a skin condition or any concerns, check with your GP or a qualified skincare professional before starting.
The bottom line
PDRN salmon DNA has earned its place in modern skincare for supporting hydration, firmness and glow. Behind the science-y name and the viral nickname is a well-loved ingredient you can absolutely use at home. Start simple, choose a concentration that suits you, and let it become a consistent part of your routine.
Shop PDRN serums & salmon DNA skincare
Frequently asked questions
What does PDRN stand for?
PDRN stands for polydeoxyribonucleotide purified DNA fragments, most often sourced from salmon, which is why it's commonly called "salmon DNA."
What does PDRN do for skin?
In cosmetic skincare, PDRN is valued for supporting the appearance of hydration, firmness and a smooth, glowing complexion, and is often used after treatments like microneedling.
What PDRN percentage should I use?
The percentage reflects the concentration in a topical product. Higher percentages suit a more intensive routine; gentler or eye-area routines may suit lower concentrations. Choose based on your skin and goals more isn't automatically better for everyone.
Is PDRN skincare the same as a Rejuran injection?
No. Rejuran is an in-clinic injectable performed by a professional. The PDRN skincare we stock is topical serums and boosters you apply at home. They're different approaches and one isn't a substitute for the other.
Where can I buy PDRN serum in Australia?
Salmon DNA Australia stocks professional-grade Korean PDRN (salmon DNA) skincare, shipped locally. Shop the range.
