Short answer: NAD+, PDRN and hyaluronic acid are three of the most talked-about biotech skincare ingredients — NAD+ is a cellular-energy coenzyme, PDRN is a gentle salmon-DNA ingredient, and HA is a hydration powerhouse. Together in a topical serum they support the look of hydrated, fresh, even-toned skin. Here's the honest breakdown. Shop the Rejuva Healer S.
Science-forward ingredients are reshaping skincare, and few combinations get more attention than NAD+ (nicotinamide adenine dinucleotide), PDRN (polydeoxyribonucleotide), and HA (hyaluronic acid). Each is interesting on its own — but it's their combination in modern skin boosters that has people talking.
NAD+: the cellular-energy coenzyme
NAD+ is a coenzyme found in all living cells, central to how cells make and use energy. Its levels are generally understood to decline with age. As a cosmetic ingredient applied topically, it's valued for slotting into a routine focused on the appearance of resilient, radiant, even-looking skin.
What we can honestly say: a topical NAD+ serum supports how skin looks and feels — it's gentle, non-stinging, and layers well. What we can't say is that it "repairs DNA" or "reverses" ageing; those are therapeutic claims, and a cosmetic isn't a medicine.
Try the VITARAN NMN Capsule Cream →
PDRN: the gentle salmon DNA ingredient
PDRN, most often purified from salmon DNA, has become a top-tier skincare ingredient thanks to how gentle and supportive it is. Cosmetically, it's loved for:
- Supporting the look of hydrated, plump skin
- Helping skin look smoother and more even over time
- A comforting feel that suits sensitive, reactive or post-treatment skin
- Being a popular companion to gentle microneedling
Hyaluronic acid: the hydration powerhouse
Hyaluronic acid (HA) is a naturally occurring molecule famed for binding moisture — a single molecule can hold up to 1,000 times its weight in water. Cosmetically it:
- Deeply hydrates from the upper layers down, fighting the look of dullness and dryness
- Helps skin look visibly plumper, softening the appearance of fine lines
- Supports a comfortable barrier by reducing trans-epidermal water loss
- Layers beautifully under NAD+ and PDRN serums
Apply HA serums after cleansing, on damp skin, before your booster and moisturiser for the best hydration.
Why the NAD+ + PDRN + HA trio works so well
The newest skin boosters don't rely on a single "star" ingredient. NAD+, PDRN and HA each bring something different — cellular-energy support, a gentle skin-conditioning feel, and deep hydration — so together they cover more bases than any one alone. The result is a routine that supports the look of fresh, hydrated, even, comfortable skin.
An expert routine using all three
- Cleanse gently, without stripping.
- HA serum on damp skin for maximum hydration.
- Booster (NAD+ & PDRN) — layer these supportive actives. Rejuva Healer S brings all three together in one serum.
- Moisturiser to seal everything in.
- SPF every morning.
Product spotlight: Rejuva Healer S
Rejuva Healer S blends high-purity PDRN (from salmon DNA), stabilised NAD+ and multi-weight hyaluronic acid in one topical serum — a science-forward formula designed for the look of renewed, hydrated, comfortable skin.
- Triple formula: PDRN + NAD+ + HA for multi-pathway, supportive skincare.
- Gentle & well tolerated: a hypoallergenic blend suitable for most skin types, including sensitive or mature-feeling skin.
- Microneedling companion: a popular topical to pair with gentle at-home microneedling or to use after a professional treatment (follow your clinician's aftercare).
How to use: apply after cleansing (and an optional HA serum). Use two to three times weekly for general maintenance, or as a course alongside treatments. Always follow with moisturiser and daytime SPF.
Most people find their skin looks more hydrated, brighter and more even over a few weeks of consistent use — a gentle, cumulative payoff rather than an overnight change.
Prefer a daily capsule routine? The VITARAN Skin Healing Series pairs 5,000 ppm PDRN with NMN (a NAD+ precursor) and encapsulated exosomes.
Frequently asked questions
What do NAD+, PDRN and HA do together?
As cosmetic ingredients they support the look of hydrated, fresh, even skin from different angles: NAD+ is a cellular-energy coenzyme, PDRN is a gentle salmon-DNA conditioner, and HA delivers deep hydration. They layer well in one routine.
Can I use this trio with microneedling?
Yes — a topical NAD+/PDRN/HA serum is a popular companion to gentle at-home microneedling (0.25–0.5mm) or to use after a professional treatment, following your clinician's aftercare.
Is it suitable for sensitive skin?
These are generally gentle, well-tolerated ingredients. Patch test first; formulas containing PDRN aren't suitable for those with fish allergies.
Disclaimer: These are topical cosmetic products, not therapeutic goods, and are not intended to diagnose, treat, cure or prevent any disease or condition. At-home microneedling should be gentle (0.25–0.5mm). Always patch test; formulas with PDRN are not suitable for those with fish allergies.
