Short answer: "Rejuran" is a clinic injectable built around salmon DNA (PDRN/PN) a procedure for qualified practitioners, not a DIY treatment. The safe at-home way to enjoy salmon DNA is a topical PDRN serum with gentle microneedling. Here's how it all fits together. Browse topical salmon DNA serums. Salmon DNA Skin Boosters
EDIT June 2026:
There have been more advanced formulations on the market since Rejuran became available in Australia back in 2024. The best one on the market currently which holds the highest % of Salmon DNA and also contains Exosomes is: Jeunetique EXOsomes PDRN 3%
What is salmon DNA (PDRN)?
Salmon DNA skincare is built around PDRN (polydeoxyribonucleotide) and PN (polynucleotide) DNA fragments purified from salmon. As a gentle, biocompatible cosmetic ingredient, it's valued for supporting the look of hydrated, calm, even skin over time.
What people love about it (cosmetically)
- Hydration: PDRN helps draw in moisture for a plump, dewy look.
- The look of smoothness: supports the appearance of softened fine lines over time.
- The look of firmness: supports a more even, resilient-looking complexion.
- Comfort: a gentle, soothing feel suited to sensitive skin.
- Low fuss: easy to use consistently with minimal downtime.
Important: Rejuran (injectable) is a clinic-only procedure
You'll often hear "Rejuran" in the context of an injectable treatment. Injecting any product beneath the skin is a clinical procedure that must be performed by a qualified, licensed practitioner in a regulated setting it carries real risks (infection, scarring, vascular and nerve injury) and is not something to do yourself at home. We don't sell injectables, and nothing here is intended to be injected. If clinical treatment interests you, book a consultation with a licensed professional.
The safe at-home alternative: topical PDRN + gentle microneedling
The good news is you can enjoy salmon DNA cosmetically at home no needles into the skin with a topical PDRN serum, optionally paired with gentle microneedling (0.25–0.5mm) to help it absorb.
What you'll want
- A topical salmon DNA (PDRN) serum
- A clean derma stamp or microneedling pen with single-use heads
- A gentle cleanser, a soothing mask, a barrier moisturiser and SPF
- Optionally, an LED red light device for a comforting finish
The gentle method
1. Cleanse and pat dry.
2. Numb only if sensitive, then wipe off excess.
3. Gently microneedle at a shallow depth (0.25–0.5mm) with clean, single-use heads. Keep plenty of serum on the skin so the device glides (dragging on dry skin can cause irritation), and never go deep enough to draw blood.
4. Apply your salmon DNA serum throughout, and coat the skin at the end — the micro-channels stay receptive for a few minutes.
5. Mask & LED (optional), then a barrier moisturiser.
Aftercare
A little redness (like mild sunburn) is normal and usually settles within a day. Avoid heavy makeup, sun, saunas, steam and exercise for at least 24 hours. For the full routine, see our aftercare guide.
How often & what to expect
A common rhythm is a gentle session every few weeks, with daily topical serum in between. Results are cumulative most people notice the look of more hydrated, even skin over several weeks. A topical at-home routine is also a budget-friendly way to enjoy salmon DNA compared with clinic visits (and, unlike a clinic injectable, it's a cosmetic you apply yourself).
Shop topical salmon DNA serums →
Final thoughts
Salmon DNA is a lovely, gentle way to support the look of healthy, radiant skin. Injectable Rejuran is a clinic procedure for qualified practitioners but for a safe, at-home cosmetic routine, a topical PDRN serum with gentle microneedling is a beautiful, needle-free option. Always prioritise skin health, and consult a professional if you're unsure.
Frequently asked questions
Can I do Rejuran at home?
No — injectable Rejuran is a clinical procedure that must be performed by a qualified practitioner. For home use, a topical salmon DNA (PDRN) serum with gentle microneedling is the safe cosmetic alternative.
Is salmon DNA skincare safe to use at home?
Yes topical PDRN serums are made for at-home use on the skin's surface, on their own or with gentle microneedling (0.25–0.5mm). No injecting.
How often should I use it?
A gentle microneedling session every few weeks, with a daily topical PDRN serum in between, works well for most people.
There have been more advanced formulations on the market since Rejuran became available in Australia back in 2024. The best one on the market currently which holds the highest % of Salmon DNA and also contains Exosomes is: Jeunetique EXOsomes PDRN 3%
Disclaimer: The products we sell are topical cosmetics, not therapeutic goods, and are not intended to diagnose, treat, cure or prevent any disease or condition, and are not for injection. Injectable treatments like Rejuran are clinical procedures for qualified practitioners only. At-home microneedling should be gentle (0.25–0.5mm). Always patch test; not suitable for those with fish allergies.
